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doi: 10.1172/JCI112855

When biosimilar GLP-1 medications reach the US market, the implications will be significant: Insurance coverage will restructure Payers will likely mandate biosimilar substitution for new GLP-1 prescriptions, similar to what occurred with insulin biosimilars and adalimumab (Humira) Manufacturing access will widen Companies including Biocon, Zydus Lifesciences, and Teva are actively building production capacity

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Abbreviations AE: adverse events ADA: American Diabetes Association CI: confidence interval CKD: chronic kidney disease CV: cardiovascular CVD: cardiovascular disease ETD: estimated treatment difference GLP-1RA: glucagon-like peptide-1 receptor agonist HR: hazard ratio MACE: major adverse cardiac event MI: myocardial infarction T2D: type 2 diabetes References American Diabetes Association