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doi: 10.1007/s10067-010-1474-7 104 FlowersMEInamotoYCarpenterPALeeSJKiemHPPetersdorfEWet al

Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]

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