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Key points Phentermine suppresses appetite short-term, and semaglutide works long-term Semaglutide achieves an average of 15%-20% weight loss versus phentermine's 5-10% Phentermine acts fast but has heart risks, and semaglutide has digestive side effects Both need diet and lifestyle changes to work effectively When you're in your doctor's office discussing weight loss medications, two names may come up: phentermine and semaglutide