average weight loss on glp 1 GLP-1 Per Month: What to Expect GLP-1 Survey: 37.5% of People

10.1016/j.jamcollsurg.2015.12.009 36 LiaoX.SongL.ZengB.LiuB.QiuY.QuH.et al (2019)

However, these results did not reach Bonferroni-corrected significance [66]

When this hormone binds to receptors in the brain, pancreas, stomach, and elsewhere, several things happen: Appetite is significantly reduced, with many patients reporting a dramatic decrease in food cravings Gastric emptying slows, meaning food stays in the stomach longer and fullness is sustained after smaller meals Blood sugar regulation improves, reducing the energy spikes and dips that typically drive overeating Interest in high-calorie and highly processed foods often reduces, an effect many patients describe as the food noise quietening Mounjaro (tirzepatide) adds a second mechanism by also activating the GIP receptor

For semaglutide specifically, here is how the two vial sizes compare at each water volume: 2mL water + 5mg vial = 2.5mg/mL vs