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p-Nitroanilide (pNA, CAS: 100-1-6) was bought from Aladdin Co

Most considerations of non-animal alternatives for skin irritation/sensitization testing tend to examine a single aspect of the process (e.g., chemical reactivity, epidermal bioavailability, dendritic cell responses)

The FDA has determined that NAC is excluded from the statutory definition of a dietary supplement under the Federal Food, Drug, and Cosmetic Act, because NAC was authorized as an active pharmaceutical ingredient (for acetaminophen overdose) before it was widely marketed as a supplement

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