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Once discontinued, many patients experience appetite rebound, making sustained weight loss challenging

One key transcription factor that plays a critical role in protecting cells from oxidative stress and xenobiotic substances is Nrf2 [88]

By contrast, in humans, treatment with a DPP4i decreased DPP4 enzyme activity but did not increase the levels of inflammatory markers 85

Irrespective of the ethnic background, the risk for CHD among diabetic subjects is greater by a factor of 2 to 4 compared to non-diabetic subjects [1]