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In Phase II detoxification, glutathione S-transferase enzymes conjugate GSH to electrophilic xenobiotics and endogenous metabolites, facilitating their excretion

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The acceleration during months 4-6 often surprises users who experienced slower progress during the adaptation period

Abbreviations AMPK: 5'AMP-activated protein kinase AP: Acute pancreatitis ARE: Antioxidant response element ATRA: All-trans retinoic acid BRB: Berberine CP: Chronic pancreatitis DAMPs: Damage-associated molecular HO-1: Heme oxygenase 1 IFN: Interferon IL: Interleukin Keap1/Nrf2: Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 LPS: Lipopolysaccharide MAPK: Mitogen-activated protein kinase NFB: Nuclear factor kappa-b NLRP3: NOD-like receptor family pyrin domain containing 3 NQO1: NAD(P)H quinone dehydrogenase 1 OS: Oxidative stress PDAC: Pancreatic ductal adenocarcinoma polyI:C: Polyinosinic:polycytidylic acid RA: Retinoic acid RAR: Retinoic acid receptor RIP3: Receptor interacting protein 3 ROS: Reactive oxygen species SOD: Superoxide dismutase TAK-242: Transforming growth factor -activated kinases VA: Vitamin A References Abdelzaher WY et al (2021) Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis