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Clinical studies have demonstrated that curcumin inhibits NLRP3 inflammasome activation via NF-B-induced P2X7R signalling in macrophages (Kong et al., 2016), and apigenin significantly reduces the mRNA and protein expression of TMAO-induced NLRP3 (Yamagata et al., 2019), which suggests that TCM could potentially treat CRC by impacting the NLRP3 inflammasome, providing a potential pathway
4,5 In the retina, pre-clinical studies have revealed potentially anti-inflammatory and neuroprotective effects independent of glucose-lowering effects
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