They have found that the spatial distribution of functional connectivity metrics correlates significantly with the spatial distribution of glucose uptake [51, 53]
Despite this correlation, many of these studies lack detailed histopathological data on these pre-existing pigmentations, complicating a clear understanding of their role in melanoma development.[8,11] It has been postulated by researchers[2,3,4,9] that when the initial presentation of a lesion is that of a flat, well-circumscribed pigmented one, it harbors the inherent potential for malignant transformation
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