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For example, patients weighing under 200 pounds were restricted to 1,200 kcal per day, patients weighing more than 300 pounds were restricted to 1,800 kcal per day, and for patients between 200 pounds and 300 pounds, body weight (in pounds) was multiplied by 6 to arrive at the daily caloric restriction

This gradual approach helps reduce gastrointestinal side effects, which are common during the early stages of treatment

Kidney Health: Slows kidney disease progression and improves overall kidney function in diabetic patients with CKD

Key considerations include: Heart rate increases: These medications may increase resting heart rate, typically by 2-4 beats per minute on average, though some patients may experience increases of 10 beats per minute or more [1] [2] Hypotension risk: Weight loss and volume depletion may affect blood pressure, particularly in patients taking antihypertensive medications Drug interactions: Delayed gastric emptying may affect absorption of some oral medications