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These include: Nausea the most frequently reported adverse effect, particularly during dose escalation Vomiting Diarrhoea Constipation Decreased appetite (which, whilst therapeutically intended, can occasionally be excessive) Abdominal discomfort or pain These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or when the dose is increased

Bostrm P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al

In-vitro fertilization, artificial insemination, and other fertility-promoting techniques may help women with endometriosis become pregnant (Giudice 2010)

The American Academy of Pediatrics emphasizes that very few drugs are absolute contraindications, and each situation should be evaluated individually