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For convenience, we decided to use HCT116 KO clones from the RESOLUTE consortium, as they were readily available and had been amply validated and characterized (Superti-Furga et al, 2020)

Carbon 63 , 471477 (2013)

Among these targets, 71 were associated with A, Tau, A, and Tau (Figure 11A), specifically, PIK3CD, CDC42, PDE4D, HTR4, ADRA1B, ARG1, PTGS1, PRF1, ADRA2A, CD81, CRYAB, BACE1, CDK2, MDM2, ALDH2, CYP19A1, NOS2, CSNK1D, PRKACA, CSNK2A1, PLCG1, CBS, and MIF were significantly associated with A pathology, EPHB2, LCK, JUN, ZAP70, DPP4, HTR2B, MAPK10, HTR1A, VEGFA, HTR1B, CFTR, CHRM2, GBA2, GSTP1, MMP3, HTR3A, CD4, VDR, MAPK3, and CHEK2 were significantly associated with Tau pathology