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However, these studies are still limited to lab only, and cant be directly applied to human use

Research article safety and tolerability of sitagliptin in clinical studies: A pooled analysis of data from 10,246 patients with type 2 diabetes

Targeting such a high capacity for CB loading is not attainable in a reasonable timeframe using a 6 min residence time, but application of in-line concentration with single-pass tangential flow filtration could help maximize resin utilization

The arginine substitution dramatically reduces IGFBP binding affinity by approximately 1,000-fold relative to native IGF-1 while the N-terminal extension contributes to extended circulating stability