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To account for variations in region lengths between main and pseudogene RNUs, the mode distance was used to scale the signal for each RNU class as follows: RNU1 (116 genes, 163 nt), RNU2 (39 genes, 190 nt) and RNU6 (505 genes, 106 nt)

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We first studied hyperpolarized [1- 13 C]dehydroascorbate in the normal rat brain, demonstrating its robust conversion to [1- 13 C]vitamin C, consistent with rapid transport of the oxidized form across the blood-brain barrier