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Miras says that many people who regain weight after medication or dieting experience a change in their body composition which could potentially be even worse for their long-term health than if they had simply maintained their existing weight

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Molecular dynamics (MD) simulations, mass spectrometry and E194A site-directed mutagenesis revealed that PARP1-mediated ribosylation of PXR E194 enhanced CYP3A4 transcription, ultimately leading to excessive NAPQI production