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Athough increase in liver size as measured by liver weight is correlated with microsomal enzyme induction, neither the degree or extent of hypertrophy nor the magnitude of the weight increase is correlated with the magnitude of the enzyme induction in rats, dogs, or monkeys (Amacher et al

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Dose-Response Evidence from Preclinical Gastroparesis Models The clearest dose-response data comes from induced gastroparesis models using either cysteamine (which causes duodenal ulcers that impair pyloric function) or L-NAME (a nitric oxide synthase inhibitor that paradoxically causes delayed emptying through vascular dysfunction)