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The peptide powerfully modulates inflammation by increasing microRNA-146a expression while decreasing pro-inflammatory cytokines including TNF-alpha, IL-6, IRAK1, and TRAF6

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Furthermore, the persistent inflammatory environment driven by inflammasomes consumes local oxygen, creating an anaerobic microenvironment in the gut that alters the microbial ecology and may contribute to the development of related diseases (e.g., inflammatory bowel disease, colorectal cancer) (Li et al., 2026)