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Because the effects of rescue medications (e.g., basal and bolus insulin) are already included in treatment policy estimands, disease modelling which equally applies treatment effects of subsequent treatments (e.g., basal and bolus insulin) following formally modelled treatment switching/intensification biases results against better-performing treatments with lower use of rescue medications

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These compounded medications are formulated by licensed pharmacies and are not subjected to the same rigorous clinical trials as brand-name drugs