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LEfSe analysis showed that one of the dominant genera in the MT group was Candidatus_ Saccharimonas , which has been associated with inflammation, lipid metabolism, and oxidative stress ( Ruminococcaceae_bacterium GD6 in this genus has been reflected in related studies on ulcerative colitis ( Blautia , which, when orally administered to mice, induces metabolic changes and anti-inflammatory effects, reducing obesity and diabetes caused by a high-fat diet, its beneficial effects are related to unique amino acid metabolism ( Research has found that semaglutide improves high-fat diet-induced obesity in mice in a dose-dependent manner

If retatrutide improves glycaemic control over time, this background risk may in fact be reduced rather than increased though this has not been specifically studied for retatrutide