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Indicative of the innovation that exists within the pipeline, more than thirty mechanisms of action are represented by the ~33% of drug candidates with mechanism of action classified as "Other", (Figure 3 c)

Since nitrous oxide is commonly used for surgery in the elderly, some experts feel vitamin B 12 deficiency should be ruled out prior to its use or prophylactic vitamin B 12 supplementation implemented before and after exposure to the gas (7, 18)

Most side effects are minor and manageable, and the biggest risks often come from using low-quality products or going it alone without a proper plan