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The mean percentage change in weight at week 72 was 15.0% (95% confidence interval [CI], 15.9 to 14.2) with 5-mg weekly doses of tirzepatide, 19.5% (95% CI, 20.4 to 18.5) with 10-mg doses, and 20.9% (95% CI, 21.8 to 19.9) with 15-mg doses

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Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK

As expected, the total intracellular -GC and GSH pools were significantly decreased in cells expressing shACTL6A (Supplementary Fig 4a, b)