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For researchers selecting between MT-I and MT-II nasal spray formats, this distinction has practical significance: MC1R selectivity correlates with fewer off-target receptor effects, while broader MCR activation correlates with more systemic melanocortin activity

Researchers from the University of Southern California and the University of California San Diego evaluated a large, nationally representative electronic health records database to determine the incidence of primary open-angle glaucoma (POAG), ocular hypertension (OHT) and first-line glaucoma interventions in patients with type 2 diabetes mellitus (DM) treated with tirzepatide vs

A 2024 study led by Wang, Volkow, and colleagues examined two cohorts totaling over 682,000 individuals with either obesity or type 2 diabetes and found the risk of new alcohol use disorder diagnoses was about 50% lower among those taking semaglutide compared to other anti-obesity or diabetes medications (Wang et al., 2024a)