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The most common models include cysteamine-induced duodenal ulceration (which impairs pyloric function), L-NAME administration (which blocks nitric oxide synthesis and causes vascular-mediated gastric stasis), NSAID-induced gastric injury with delayed emptying, and streptozotocin-induced diabetic gastroparesis in rats

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During lyophilization, peptides are frozen and exposed to controlled low-pressure conditions

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