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In summary, HFR is a highly biocompatible procedure, with good clinical tolerance and cardiovascular stability, in which convection is separated from diffusion, eliminating the potential risk of retrofiltration

Firstly, the permeability of EBA increased after 24-h incubation with 3-PLG-ibu, and secondly, in inflammatory condition besides the 3-PLG-ibu-A-GSH the free ibuprofen treated group also significantly strengthened the integrity of the BBB model for the bigger transcellular marker molecule (Fig

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