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The PIONEER 6 cardiovascular outcomes trial demonstrated that oral semaglutide was non-inferior to placebo for major adverse cardiovascular events (MACE) in high-risk patients
Non-Medicare members in the largest plan designs will have minimal cost-sharing increases for emergency room copays, deductibles, out-of-pocket limits, and drug copays and coinsurances
By modulating macrophage polarization towards an M2 subtype, GLP-1RAs can inhibit inflammation occurring in the vessel lumen, an action which would alleviate the progression of atherosclerosis (Figure 2)
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