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Healthcare providers may recommend evidence-based behavioral therapy and lifestyle modifications tailored to each individuals circumstances to address the root causes of obesity

There is evidence that metformin can increase the abundance of microbiota which can all produce SCFAs such as Butyrivibrio , Bifidobacterium , Megasphaera , Prevotella , and so on (de la Cuesta-Zuluaga et al., 2017)

More recently, the SELECT trial showed that semaglutide 2.4 mg reduced major adverse cardiovascular events in adults with overweight or obesity without diabetes