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In co-culture of lipopolysaccharide-activated microglia with astrocytes, cytokine/chemokine dynamics are affected not only by activated microglia, but also by the crosstalk between astrocytes and activated microglia [56]

In addition to acute medicine use (see: Prescribe a NSAID, corticosteroid or colchicine to treat gout flares), encourage rest and elevation of the affected joint, adequate hydration, and some patients may find an ice pack beneficial