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The direct downstream targets of mTORC1 are ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4Ebinding proteins (4EBP) which regulate protein translation, cell size and cell cycle progression 7,8
Furthermore, studies have shown anti-inflammatory and antioxidant activity [31]
Outcome Focus: The trials were designed primarily to assess weight loss efficacy, with safety as a secondary outcome
This interaction was mapped at the hydrophobic domain of G0S2 and the patatin-like domain of PNPLA2, whereby overexpression of G0S2 diminished adipocyte lipolysis, and deletion increased both basal and stimulated lipolysis (52)
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