Severino A, Abbruzzese C, Manente L, Avivar Valderas A, Mattarocci S, et al
A beautiful night celebrating #Time100 , the pop star gushed via Instagram one day later on Friday, April 26, sharing footage of her musical set
In recent years, the landscape of weight-loss injections has shifted dramatically: from older GLP-1 medications to dual-agonists such as Mounjaro , and now to even more ambitious agents such as Retatrutide
Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)