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Based on this result, we further explored the mechanism of the drug pair from nuclear factor erythroid 2-related factor2/Hemeoxygenase-1(Nrf2/HO-1) pathway (Gong et al., 2017)

10.1136/gutjnl-2014-307720 245

RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks

8 weeks (6 vials): 18 mL 2 10 mL bottles 12 weeks (8 vials): 24 mL 3 10 mL bottles 16 weeks (11 vials): 33 mL 4 10 mL bottles Alcohol Swabs: One for the vial stopper + one for the injection site each day