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Wang W-L, Chen K-H, Pan Y-C, Yang S-N, Chan Y-Y

There are multiple compensatory mechanisms for glycocalyx damage, such as an increase in the expression of tight junction proteins and changes in cytoskeletal structure, which help maintain the normal function of microvessels (103) and further delay the effects

Overall, tryptophan metabolism produces bioactive metabolites with both pro- and anti-fibrotic properties through mTOR, Smad, PI3K/AKT, and AhR-dependent pathways

Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272