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Insulin resistance was estimated using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), calculated as fasting insulin (U/mL) fasting glucose (mmol/L)/22.5

For a deeper look at how GLP-1s fit into weight management, see our guide on what GLP-1 is and how it can transform weight loss

Gastrointestinal issues, including nausea, vomiting, diarrhea and headaches, are commonly reported side effects of GLP-1s, according to the Mayo Clinic

Cold-turkey discontinuation may set up regain because four forces converge: appetite returns as the drug washes out, lean mass lost during the deficit is already gone, retatrutides glucagon-arm metabolic lift fades fast, and hunger-hormone defenses persist for about 12 months after major weight loss