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Patients with severe kidney disease (eGFR below 2030) Patients with recurrent UTIs or fungal infections Type 1 diabetes patients (unless specifically prescribed) Pregnant women References: Protective Influence of SGLT-2 Inhibitors Against Heart Failure PMC 2024 Clinical Evidence for Cardiovascular & Kidney Benefits PMC SGLT2 Inhibitors: Antidiabetic and Cardioprotective Effects PMC Emerging Horizons: SGLT-2 Inhibitors Beyond Diabetes PMC DPP-4 inhibitors, sulfonylureas, TZDs So far we have covered the star players Metformin, GLP-1 agonists, and SGLT2 inhibitors