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Clin Pharmacol Ther 84(6):662673 [DOI] [PMC free article] [PubMed] [Google Scholar] Kim RB, OShea D (1995) Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms

[1] Another COMT inhibitor entacapone was released in 1999 which was not liver-toxic but still caused dyskinesias, nausea, diarrhea, abdominal pain, and urine discoloration