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NICE guidelines recommend at least annual renal function testing for all patients with type 2 diabetes

Expression of GLP-1 receptors in the ocular region While the pharmacokinetic properties of GLP-1RAs determine their systemic availability, their therapeutic potential in ocular diseases is fundamentally contingent upon the presence and localization of GLP-1 R in target tissues

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These agents increase stool bulk and stimulate peristalsis, though adequate fluid intake is essential to prevent worsening constipation