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Additionally, exposure to oridonin (ORI) at concentrations of 25 M (M) or higher for 48 h notably elevates cytosolic Ca 2+ concentration, promotes ceramide formation, and induces erythrocyte death through suicidal pathways ( To address these challenges, the development of advanced drug delivery systems is essential to improve ORIs solubility, enhance bioavailability, and reduce toxicity (Table 2

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