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Intake of higher doses doesnt appear to be associated with detrimental health problems.2 The VNDPG recommends the following B12 guidance2: All vegetarians, regardless of type, should periodically be screened for B12 deficiency, using either methylmalonic acid (MMA) or TCII (transcobalamin) assessment

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For these localized applications, systemic absorption may matter less than direct contact with digestive tissues