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Second, glutathione synthetase adds glycine to form GSH

Although the primary function of mitochondria is to generate ATP as an energy molecule required for countless cell functions, a small fraction of electrons from the ETC are transferred directly to O 2 , resulting in the generation of the superoxide anion, which can give rise to other ROS as well as reactive nitrogen species (RNS)

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Consistently, FAC alone induced ferroptotic death in osteocytes, but co-treatment with LCN2 markedly increased the susceptibility of osteocytes to FAC-induced ferroptosis, indicating a compounding effect (Fig