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Abbreviations AMPK: 5-AMP-activated protein kinase CHT: Choline transporter DPP4: Dipeptidyl peptidase-4 DR: Delayed release 18 F-FDG: 18 F-fluorodeoxyglucose FXR: Farnesoid X receptor GI: Gastrointestinal GIMM: Gastrointestinal microbiome modulator GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide 1 GoDARTS: Genetics of Diabetes and Audit Research Tayside Study 5-HT: Serotonin NMDA: N -methyl-d-aspartate OCT: Organic cation transporter PET-CT: Positron emission tomographycomputed tomography PKA: Protein kinase A PMAT: Plasma membrane monoamine transporter SERT: Serotonin transporter SGLT1: Sodiumglucose transporter 1 References Bailey CJ, Day C (1989) Traditional plant medicines as treatments for diabetes