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Theres much conjecture as to what causes leg cramps during sleep, but a few common causes include: Mineral deficiencies in calcium, magnesium and potassium Deficiencies in vitamins A, B and E Medical conditions like liver failure, cirrhosis, kidney disease, diabetes, hypothyroidism A fluid/electrolyte imbalance Dehydration, especially after exercise Prescription medications such as diuretics, statins and bronchodialators for asthma Dr

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