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In contrast to wild-type AAV, recombinant AAV (rAAV) replaces the viral genes between the ITR sequences with a therapeutic transgene (Fig
To view a copy of this licence, visit About this article Cite this article Sugawara, T., Hitaka, K., Matsumoto, M
After endocytosis, intracellular glutathione cleaves disulfide bonds in the carrier matrix and releases the payload, a design principle detailed in recent reviews of stimuli-responsive polymers [204, 205]
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