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Overall, the structure is highly similar to the inward-facing conformation, and again, there is density that we attribute to Na + at the same binding site, albeit slightly weaker in intensity (Supplementary Fig

Srivastava KD, Kattan JD, Zou ZM, Li JH, Zhang L, Wallenstein S, et al

10.1021/acs.jproteome.9b00806 215

Furthermore, rodents do not easily develop addictive behaviour, naturally decrease alcohol consumption as acetaldehyde levels rise, metabolize alcohol quickly, have a high basal metabolic rate and demonstrate certain differences in the innate immune system 140