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In research trials of higher oral doses of semaglutide, participants lost up to 15% of their body weight when paired with healthy lifestyle changes

The researchers specifically noted this finding "could provide reassurance that a greater proportion of lean mass is not lost with retatrutide despite the overall increased weight loss." For a bodybuilder interpreting this data, the practical implication is clear

By supporting barrier integrity and reducing inflammation, these peptides may decrease autoimmune triggers originating in the gut