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Tryptophan metabolites , particularly indole derivatives produced by Lactobacillus species and Akkermansia muciniphila , promote L cell differentiation and activate GLP-1 secretion via GPR142 and the aryl hydrocarbon receptor
People who start out at a higher BMI typically see faster results and greater percentage of weight loss than others
Preliminary results from a late-stage trial involving adults with obesity and knee osteoarthritis showed average weight loss of about 28.7% after 68 weeks, suggesting the drug may be even more effective than earlier treatments
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