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Among these, compounds 53 (IC 50 = 4 nM) and 54 (IC 50 = 10 nM) exhibited high DPP-4 inhibitory activities, good efficacy, and selectivity in an oral glucose tolerance test in ICR mice (Figure 7)

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Furthermore, in adolescents and adults with K ATP hyperinsulinism, a continuous intravenous infusion of exendin-(9-39) resulted in higher fasting plasma glucose concentrations and lower insulin to glucose ratio

Stem cell systems have non-stem niche cells that signal nearby cells to promote the stem cell fate/self renewal and to inhibit differentiation