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the remainder reaches the colon and may be fermented or excreted in faeces

These can include disorders such as VLCAD or MCAD, or disorders related to problems in the carnitine cycle in the mitochondria due to defective enzymes

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Because the combination regimen allowed for a slightly lower dose of fumaric acid esters, the researchers concluded that the risk-benefit ratio favored calcipotriol plus fumaric acid esters over fumaric acid esters alone (Gollnick 2002)