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The documented synergy comes from pairing a GHRH analog with a GHRP, which acts on a different receptor: Ipamorelin GHRP-2 GHRP-6 Blends pairing two GHRH analogs are sold, but the supra-additive GH release reported in the literature comes from the GHRH + GHRP pairing

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When growth hormone binds to receptors in muscle, bone, cartilage, and organ tissues, it stimulates protein synthesis, cell proliferation, tissue hypertrophy, and structural growth