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The evidence on the distribution and effects of GIP receptors in the lungs is limited, and further research is necessary to elucidate their role in the pulmonary immune response [16]

Comprehensive safety studies spanning six months in rats (up to 100 mg/kg/day) and nine months in cynomolgus monkeys (up to 50 mg/kg/day) revealed no adverse findings, with NOAEL reaching the highest applied dosages

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Starting at a lower dose (0.25 mg or 1.7 mg) and increasing more gradually over 46 weeks instead of the standard 4-week ramp allows your body to acclimate to metabolic changes with less acute inflammation