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IL-18 can activate intestinal epithelial cells to produce antimicrobial peptides (AMPs) and stimulate the production of Th1, NK and NKT to secrete IFN-, or combine with IL-12 to induce more IL-17-secreting T cells [102, 103]

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Lifestyle changes: If your main concern is muscle loss or energy rather than fat loss, resistance training combined with adequate protein intake remains the most evidence-backed approach