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The human equivalent dose for the cyano- and methyl-cobalamin drinking water used in these studies is ~5000 g/day (CNCbl10 & MeCbl10) and ~25,000 g/day (CNCbl40 & MeCbl40), which was calculated using the standard human equivalent dose parameters [18]

[10] Other uncommon adverse effects reported with very high doses include dermatological lesions (photosensitivity and skin rash), gastrointestinal upset, and in some cases dependency syndromes (e.g